Yael Gazit, Giris Jacob, and Rodney Grahame.
Throughout the years, extra-articular manifestations have been described, including cardiovascular,
autonomic nervous system, gastrointestinal, hematologic, ocular, gynecologic, neurologic, and psychiatric
manifestations, emphasizing the multisystemic nature of EDS-HT. Unfortunately , EDS-HT is underrecognized
and inadequately managed, leading to neglect of these patients, which may lead to severe disability that almost certainly could have been avoided. In this review article we will describe the known
manifestations of the extra-articular systems.
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